Department of Reproductive Medicine

Jeffrey Chang

R. Jeffrey Chang, M.D.
Professor Emeritus of Reproductive Medicine
Division of Reproductive Endocrinology and Infertility

Telephone:
(858) 534-8930
Fax:
(858) 534-8856
Email:
rjchang@ucsd.edu


Education

1961-65

University of Oregon, Eugene, Oregon (BA)

1965-69

University of Oregon Medical School, Portland, Oregon (MD)


Postgraduate Training

1969-70

Intern, Medicine, Barnes Hospital, St. Louis, Missouri

1970-74

Resident, Obstetrics and Gynecology, Harbor General Hospital, Torrance, California

1974-75

Postdoctoral Fellowship, Reproductive Endocrinology, Division of Reproductive Biology, Obstetrics and Gynecology, Harbor General Hospital, Torrance, California

1975-77

Postdoctoral Fellowship, Reproductive Endocrinology, Reproductive Endocrinology Center, Obstetrics and Gynecology, University of California Medical Center, San Francisco, CA


Academic Appointments

1977-86

Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, California

1986-96

Department of Obstetrics and Gynecology, UCD School of Medicine, Davis, California

1987-96

Chair, Department of Obstetrics and Gynecology, UCD School of Medicine, Davis, California

1997-

Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California


Professional Certifications

1970

National Board of Medical Examiners

1971

State of California Board of Medical Examiners (Lic#G20109)

1977

Diplomat of the American Board of Obstetrics and Gynecology

1980

Diplomat of the American Board of Obstetrics and Gynecology, Subspecialty of Reproductive Endocrinology

1994

American Board of Obstetrics and Gynecology, Recertification

1994

American Board of Obstetrics and Gynecology, Subspecialty of Reproductive Endocrinology, Recertification


Professional Membership/Service

NIH Reproductive Biology Study Section Member 1989-1993, Chair 1989-1993;

NIH Physiological Sciences Review Section Administrative, Chair 1991-1993;

American Board of Obstetrics and Gynecology Examiner, Subspecialty Board (Reproductive Endocrinology) 1992-Present;

American College of Obstetricians and Gynecologists GYN Practice Committee Chair 1994-95,

Subcommittee on Reproductive Endocrinology Practice Chair 1991-93, 1997-99,

Document Review Panel on Gynecology Vice-Chair 2001-02,

ACOG Section I, District IX Chair 1993-96;

Pacifici Coast Reproductive Society President 1989-90;

Society of Reproductive Endocrinologyists President 1990-92;

Association of Professors of Gynecology and Obstetrics President 1994-95;

American Society from Reproductive Medicine President 1999-2000,

UCSD Medical Center Chief of Staff 2003-2005.

Selected Publications (From a Total of 170 Published or In Press; 1974 - Present)

Chang RJ, Mandel FP, Lu KH, Judd HL. Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease. J Clin Endocrinol Metab 54:490-494, 1982.

Chang RJ, Laufer LR, Meldrum DR, DeFazio J, Lu KH, Vale WW, Rivier JE, Judd HL. Steroid secretion in polycystic ovarian disease after ovarian suppression with a long-acting gonadotropin-releasing hormone agonist. J Clin Endocrinol Metab 56:897-903, 1983.

Chang RJ, Nakamura R, Judd HL, Kaplan SA. Insulin resistance in non-obese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57:356-359, 1983.

Steingold K, de Ziegler D, Cedar M, Meldrum DR, Lu KH, Vale WW, Rivier JE, Judd HL, Chang RJ. Clinical and hormonal effects of chronic long-acting gonadotropin-releasing hormone agonist treatment in polycystic ovarian disease. J Clin Endocrinol Metab 65:773-778, 1987.

de Ziegler D, Steingold K, Cedars M, Lu KH, Judd HL, Chang RJ. Recovery of hormone secretion after chronic gonadotropin-releasing hormone agonist administration in women with polycystic ovarian disease. J Clin Endocrinol Metab 68:1111-1117, 1989.

Erickson GF, Magoffin DA, Cragun JR, Chang RJ. The effect of insulin and insulin-like growth factors I and II on estradiol production by granulosa cells of polycystic ovaries. J Clin Endocrinol Metab 70:894-902, 1990.

Erickson GF, Magoffin DA, Garzo G, Cheung AP, Chang RJ. Granulosa cells of polycystic ovaries: are they normal or abnormal? Hum Reprod 7:293-299, 1992.

Cheung AP, Lu JKH, Chang RJ. Pulsatile gonadotropin secretion in women with polycystic ovary syndrome after gonadotropin-releasing hormone agonist treatment. Hum Reprod 12: 1156-1164, 1997.

Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF. A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci 96:7282-7287, 1999.

Chang RJ. Polycystic ovary syndrome: Diagnostic criteria. In Polycystic Ovary Syndrome: Basic Biology and Clinical Intervention (eds: Chang RJ, Dunaif A, Heindel J) Marcel Dekker, 2002

Coffler MS, Patel K, Dahan MH, Yoo RY, Malcom PJ, Chang RJ. Enhanced granulosa cell responsiveness to follicle stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone J Clin Endocrinol Metab 88:5624-5631, 2003.

Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ, Chang RJ. Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab 88:5456-5461, 2003.

Yoo RY, Dewan A, Basu R, Newfield R, Gottschalk M, Chang RJ. Increased luteinizing hormone pulse frequency in obese oligomenorrheic girls with no evidence of hyperandrogenism. Fertil Steril 85: 1049-56, 2006.

Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clin Endocrinol Metab 93:1827-1833, 2008.

Faculty