Heidi Cook-Andersen, M.D., Ph.D.
Link to Dr. Cook-Andersen's Lab
|MD||Yale University School of Medicine, 2005|
Molecular Biophysics and Biochemistry
Yale University Graduate School of Arts and Sciences, 2005
Obstetrics and Gynecology
University of Colorado Health Sciences Center, 2005-2009
Reproductive Endocrinology and Infertility
University of California, San Diego, 2009-2010
Reproductive Endocrinology and Infertility
University of California, San Diego, 2010-2013
University of California, San Diego, 2013-present
Women's Reproductive Health Research Scholar, 2012-present
Board certified in Obstetrics and Gynecology, 2013
Honors and Awards
- Prize presentation, WRHR Scholar Conference, 2013
- Women's Reproductive Health Research Scholar grant recipient, 2012
- Excellence in Humanism and Teaching Award, final nominee, University of Colorado Health Science Center, 2007
- MD/PhD Award for Excellence in Research and Medicine; Yale University, 2005
- Howard Hughes Medical Institute Predoctoral Fellowship, Yale University, 1999-2003
- Alpha Omega Alpha Honor Medical Society, Yale Medical School, 2005
- Honors Scholarship (full-tuition), Southern Methodist University,1989-1991
- Summa Cum Laude, Southern Methodist University, 1991
- Phi Beta Kappa, Southern Methodist University, 1991
- Departmental Distinction, Southern Methodist University, 1991
Molecular basis of ovarian aging
Early embryo development
Post-transcriptional regulation of gene expression
My laboratory is interested in understanding the molecular events that occur during the transition from the fully-grown, fully-differentiated oocyte to the totipotent embryo with the goal of improving embryo development and IVF outcomes. This transition occurs in the absence of transcription and, therefore, depends on posttranscriptional regulation of cytoplasmic maternal mRNAs accumulated in the oocyte at the time of ovulation. At the end of this transition, transcription resumes from the reprogrammed embryonic genome. It is clear that events during this early transition are absolutely critical for successful development of human embryos in vitro to the blastocyst stage. We currently have several projects underway investigating the mechanisms that regulate the stability and translation of maternal mRNA during the oocyte to embryo transition and to test the role of these pathways during this critical stage of embryo development.
Shayya RF, Rosencrantz MA, Chuan SS, Cook-Andersen H, Haggan A, Roudebush WE, Shimasaki S, and Chang RJ. (2013). Inhibin B Responses Following Intravenous hCG Administration are Decreased in Normal Women but not in Women with Polycystic Ovary Syndrome. Fertility and Sterility, in press.
Chang, RJ, Cook-Andersen, H. (2013). Disordered Follicle Development in PCOS. Molecular and Cellular Endocrinology 373(1-2):51-60.
H Cook-Andersen, MC Howe, E Shum, DJ Stumpo, PJ Blackshear, and MF Wilkinson. Poster presentation. "Post-transcriptional Regulation of Maternal mRNA during Early Embryogenesis." Women's Reproductive Health Research Symposium; Denver, Colorado, 2013.
AM Rosen, MC Hermoso, H Cook-Andersen, D de Ziegler, and DR Meldrum, H Cook-Andersen, and D Meldrum. "Purification of Human Chorionic Gonadotropin (hCG) for Intrauterine Injection." Poster Presentation. Pacific Coast Reproductive Society; Indian Wells, California, 2013.
H Cook-Andersen, SS Chuan, HI Su, and RJ Chang. "The effect of Luteinizing Hormone on Anti-Mullerian Hormone Levels in Polycystic Ovary Syndrome." Poster presentation. American Society for Reproductive Medicine annual meeting; San Diego, California 2012.
H Cook-Andersen, DJ Stumpo, PJ Blackshear, and MF Wilkinson. Poster presentation. "Maternal mRNA Stability during the Oocyte to Embryo Transition." Poster presentation. Women's Reproductive Health Research Symposium; Philadelphia, Pennsylvania, 2012.
K Mass, SS Chuan, H Cook-Andersen, HI Su, and RJ Chang. "Phenotypically Distinct Theca Cell Responses to Gonadotropin Administration in Women with Polycystic Ovary Syndrome." Poster presentation. American Society for Reproductive Medicine annual meeting; Boston, Massachusetts, 2012.
H Cook-Andersen, S Komrokian, A DeMichele, and HI Su. "Breast Cancer Patients Have Lower Rates of Contraception Use." Poster presentation. American Society for Reproductive Medicine annual meeting; Orlando, Florida, 2011.
H Cook-Andersen, RJ Chang and S Shimasaki. "The Role of GDF-9 in Primary Follicle Growth." Poster presentation. Oncofertility Consortium Conference; Northwestern University, Chicago, Illinois, 2010.
H Cook-Andersen, MJ Stevens, WB Schoolcraft, and MG Katz-Jaffe. "Male Factor Infertility is Associated with Chromosomally Complex Embryos." Poster presentation. American Society for Reproductive Medicine annual meeting; San Francisco, California, 2008.
H Cook-Andersen, SA Foley, K Davidson, R Alvero, W Schlaff and R Alvero. "HDL Levels and Menstrual Cyclicity Improve with a High Protein, Low Glycemic Index Diet for Weight Loss in Polycystic Ovarian Syndrome." Poster presentation. Society for Gynecologic Investigation annual meeting; San Diego, California, 2008.
Cook, HL, Lytle, JR, Mischo, HE, Li, M-J, Rossi, JJ, Silva, DP, Desrosiers, RC, and Steitz, JA. (2005). Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells. Current Biology 15(10):974-979.
Cook, HL, Mischo, HE, and Steitz, JA. (2004). The Herpesvirus saimiri Small Nuclear RNAs Recruit AU-Rich Element-Binding Proteins but Do Not Alter Host AU-Rich Element-Containing mRNA Levels in Virally Transformed T Cells. Molecular and Cellular Biology 24:4522-4533.