Department of Reproductive Medicine

Antoni J. Duleba

Antoni J. Duleba, M.D.
Professor of Reproductive Medicine
Director, Division of Reproductive Endocrinology and Infertility

Lab Telephone:
(858) 534-8930
(858) 534-5693

Education and Training

University of British Columbia Medical School, Vancouver, British Columbia

Post Graduate Training

1987-1988    Rotating Internship, St. Paul's Hospital, Vancouver, British Columbia

1988-1992    Residency: University of British Columbia, Obstetrics and Gynaecology
Vancouver, British Columbia

1992-1994    Fellowship: Reproductive Endocrinology, Yale University School of Medicine, Department of Obstetrics & Gynecology, New Haven, Connecticut

Academic Appointments

1994-1999    Assistant Professor, Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut

1999-2007    Associate Professor, Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut

2012-present    Professor, Department of Reproductive Medicine, University of California San Diego, La Jolla, California

Board Certification

1992    Fellow of the Royal College of Physicians and Surgeons of Canada, Specialist, Certified in Obstetrics and Gynecology

1995    Board Certified in Obstetrics and Gynecology, American Board of Obstetrics and Gynecology

1995    Charter member of the Accreditation Council for Gynecologic Endoscopy: Certified in Advanced Operative Laparoscopy and Advanced Operative Hysteroscopy

1996    Fellow of the American College of Obstetrics and Gynecology

1997    Board Certified in Reproductive Endocrinology and Infertility, American Board of Obstetrics and Gynecology

1992    Medical License, State of Connecticut

2007    Medical License, State of California

Professional Membership/Service

National Institutes of Health, reviewer since 2002

American Gynecological and Obstetrical Society

Society for Gynecologic Investigation

American Society of Reproductive Medicine

The Endocrine Society

Recent Publications (From a Total of 120)

Duleba AJ, Spaczynski RZ, Olive DL and Behrman HR: Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells. Biol Reprod 56:891-897, 1997.

Diamanti-Kandarakis E, Mitrakon A, Raptis S, Tolis G, Duleba, AJ: The effect of a pure antiandrogen receptor blocker flutamide on lipid profile in polycystic ovary syndrome. J Clin Endocrinol Metab 83(8): 2699-2705, 1998.

Duleba AJ, Spaczynski RZ, Olive DL, Behrman HR: Divergent mechanisms regulate proliferation/survival and steroidogenesis of theca-interstitial cells. Molecular Hum Reprod 5(3) 193-198, 1999.

Duleba AJ, Pehlivan T, Carbone R., Spaczynski RZ. Activin stimulates proliferation of rat ovarian thecal-interstitial cells. Biol Reprod 65:704-9, 2001.

Duleba AJ, Heppard MC, Soderstrom RM, Townsend DE. A randomized study comparing endometrial cryoablation and rollerball electroablation for treatment of dysfunctional uterine bleeding. J Am Assoc Gynecol Laparoscopists. 10(1): 17-26, 2003.

Duleba AJ, Banaszewska B, Spaczynski R, Pawelczyk L. Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile and insulin levels. Fertil Steril, Vol. 79(4): 1008-1014, 2003.

Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman H. Proliferation of Ovarian Theca-Interstitial Cells is Modulated by Antioxidants and Oxidative Stress. Hum Reprod. 19:1519-24, 2004.

Duleba AJ, Banaszewska B, Spaczynski RZ, Pawelczyk L. Simvastatin improves endocrine and metabolic aspects of polycystic ovary syndrome: results of prospective randomized trial. Fertil Steril. 85:996-1001, 2006.

Piotrowski PC, Kwintkiewicz J, Rzepczynska IJ, Seval Y, Cakmak H, Arici A, Duleba AJ. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biol Reprod, 75:107-11, 2006.

Diamanti-Kandarakis E, Piperi C, Papavassiliou AG, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Duleba AJ. Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol. 127:581-9, 2007.

Kodaman PH, Duleba AJ. HMG-CoA Reductase Inhibitors. Do They Have Potential in the Treatment of Polycystic Ovary Syndrome? Drugs, 68(13):1771-85, 2008.

Bruner-Tran KL, Osteen KG, Duleba AJ. Simvastatin protects against the development of endometriosis in a nude mouse model. J Clin Endocrinol Metab. 94:2489-94, 2009.

Rzepczynska J, Piotrowski PC, Wong DH, Cress AB, Villanuvea J, Duleba AJ. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth. Biol Reprod 81:850-5, 2009.

Bruner-Tran K, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro. Biol Reprod. 84: 106-112. ; 2011.

Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ. Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment. J Clin Endocrinol Metabol. 96: 3493-501; 2011.

Sokalska, A, Duleba, AJ. Medical Therapies: Statins. Chapter 36, pp: 367-384. In: L Giudice, H Evers and D Healy (eds). Endometriosis: Science and Practice. Wiley-Blackwell, Oxford, England. 2012.

Ortega I, Villanueva J, Wong DH, Cress AB, Sokalska A, Stanley S, Duleba AJ. Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway, Endocrinology,153:4019-29, 2012.

Villanueva J, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen K, Duleba AJ. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metabol, 98:E455-62. 2013.