Department of Reproductive Medicine

Cheryl Saenz

Clinical Professor
University of California, San Diego
School of Medicine

Moores UCSD Cancer Center
Division of Gynecologic Oncology
3855 Health Sciences Drive Mail Code: 0987
La Jolla, CA 92093-0987
Academic Office: (858) 822-6199
Clinic Appointments: (858) 822-6100
Laboratory: (858) 534-7778
Fax: (858) 822-6319
E-mail: csaenz@ucsd.edu


EDUCATION

COLLEGE: Cornell University
College of Arts and Sciences
Ithaca, NY
B.A. 1979-1985
Biopsychology

MEDICAL SCHOOL: University of California, Irvine
College of Medicine
Irvine, CA
M.D. 1987-1991

POSTDOCTORAL TRAINING

Resident in Reproductive Medicine
University of California Medical Center
San Diego, CA
1991-1995

Galloway Fellow
Memorial Sloan-Kettering Cancer Center
New York, NY
1993

Fellow in Gynecologic Oncology
Memorial Sloan-Kettering Cancer Center
New York, NY
1995-1998

Junior Faculty Mentoring Fellowship
National Center for Leadership in Academic Medicine
University of California, San Diego
San Diego, CA
2001

Women’s Reproductive Health Research Scholars Program
Principal Investigator: Thomas R. Moore, M.D.
Mentor: Steven F. Dowdy, Ph.D.

Departments of Reproductive Medicine and Cellular and Molecular Medicine
University of California, San Diego
Agency: NIH HD-99-001

Research Career Development Center in Reproductive Sciences
Fellow, September 2002 – February 2007

CERTIFICATION

LICENSING

ACADEMIC APPOINTMENTS

Assistant Clinical Professor
Division of Gynecologic Oncology
Department of Reproductive Medicine
University of California, San Diego School of Medicine
October 1998 – June 2004

Associate Clinical Professor
Division of Gynecologic Oncology
Department of Reproductive Medicine
University of California, San Diego School of Medicine
July 2004 – present

Interim Director, Infusion Center
Moores Cancer Center
University of California San Diego Medical Center
December 2006 – April 2007

Director, Access
University of California, San Diego Medical Center
August 2007 – present

SCIENTIFIC AND MEDICAL SOCIETIES

1995 - Present Fellow, American College of Obstetrics and Gynecology

1999 - Present Diplomat, American Board of Obstetrics and Gynecology

1998 - Present Full Member - Society of Memorial Gynecologic Oncologists

1999 - Present Full Member - Society of Gynecologic Oncologists

Marketing and Communications Committee

2000 - Present San Diego Gynecologic Society

2001 - Present Full Member

Western Association of Gynecologic Oncologists

2001 – Present Fellow, American College of Surgeons

2002 - Present Member, Media Response Team

Gynecologic Cancer Foundation

HOSPITAL COMMITTEES

1999 – Present Member, Cancer Committee
University of California San Diego, Medical Center

2001 – Present Chair, Cancer Committee
University of California San Diego, Medical Center

2002 – Present Co-Leader, Gynecologic Oncology
Specialized Cancer Units
Moores UCSD Cancer Center

2005 – Present Member, Service Excellence Committee
Moores UCSD Cancer Center

2006 – Present Subcommittee Leader, Programs of Excellence, Strategic Planning Committee
Moores UCSD Cancer Center

2007 – Present Member, Cancer Center Cabinet Moores UCSD Cancer Center

HONORS AND ACTIVITIES

Analysis of Assembly Bill 547 - Ovarian Cancer Screening

California Health Benefits Review Program

A Report to the 2003-2004 California Legislature

Director, Ovarian Cancer Survivors Course

Moores UCSD Cancer Center/Gynecologic Cancer Foundation

January 2006

Walter T. Danreuther Award

The American Association of Obstetricians and Gynecologists Foundation

September 2006

Board of Directors

Gynecologic Cancer Foundation

March 2007 – Present

Leader, Internal Task Force

Comprehensive Patient Safety Audit

Moores Infusion Center

April 2007

HOSPITAL APPOINTMENTS

Associate Clinical Professor
UCSD Medical Center – San Diego, CA
10/98 – Present

Attending Physician
Scripps Mercy Hospital – San Diego, CA
1/99 – Present

Attending Physician
Scripps Memorial Hospital – San Diego, CA
1/99 – Present

Attending Physician
Scripps Memorial Hospital - Chula Vista, CA
1/99 – Present

Attending Physician
Scripps Memorial Hospital – Encinitas, CA
1/99 – Present

Attending Physician
Sharp Mary Birch Hospital - San Diego, CA
5/99 - Present

Attending Physician
Sharp Memorial Hospital - San Diego, CA
5/99 - Present

Attending Physician
Grossmont Hospital - San Diego, CA
10/99 - Present

Attending Physician
Palomar Hospital - Escondido, CA
11/99 - Present

Attending Physician
Children's Hospital - San Diego, CA
10/99 - Present

Attending Physician
Tri-City Hospital - Oceanside, CA
11/99 – Present

Attending Physician
Pomerado Hospital - Poway, CA
11/99 – Present

SELECTED LECTURESHIPS AND PRESENTATIONS

"Ten-year Trends in Pre-invasive and Invasive Cervical Neoplasia in Southern California", Western Association of Gynecologic Oncologists, 1995.

"Pathological Risk Factors and Outcomes for Isolated Adnexal Metastases in Endometrial Cancer", Society of Memorial Gynecologic Oncologists, 1996.

"Clinicopathologic Features of Endometrial Cancer Occurring in Patients with a Family History Suspicious for Hereditary Nonpolyposis Colorectal Cancer", Society of Gynecologic Oncologists, 1998.

"Fertility Agents and the Risk of Ovarian Cancer", Grand Rounds, Department of Reproductive Medicine, University of California, San Diego, 1999.

"The Use of Operative Laparoscopy in Gynecologic Oncology", A Gynecologic Oncology Update Seminar, San Diego, CA, 1999.

"Fertility Agents and the Risk of Ovarian Cancer", San Diego Gynecologic Society, San Diego, CA, 1999.

"Ovarian Cancer" Lecture Hematology/Oncology Fellows, Veterans Administrative Hospital, San Diego, CA, 2000.

"Gynecologic Cancer Screening in the Year 2000", UCSD Cancer Center Associates Meeting, San Diego, CA, 2000.

"Abnormal Pap Smears", Advances in Urology and Gynecology for Primary Care Seminar, San Diego, CA, 2000.

"Advances in Gynecologic Cancer Treatment", The Wellness Community, San Diego, CA, 2000.

"Gynecologic Oncology Cancer Survivorship", Cancer Survivorship Seminar, San Diego, CA, 2000.

"Screening Your Patient Over 40 for Gynecologic Malignancies", Current Trends in Women's Health Seminar, San Diego, CA, 2000.

"Abnormal Pap Smears", Advances in Urology and Gynecology for Primary Care Seminar, San Diego, CA, 2001.

"Update in Gynecologic Cancers", Advances in Urology and Gynecology for Primary Care Seminar, San Diego, CA, 2002.

"Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide", Grand Rounds, Department of Reproductive Medicine, University of California San Diego, 2004.

"Selective Targeting and Killing of Tumor Cells Expressing Tumor-Associated Receptors by Transducible Anti-Cancer Peptides", Women's Reproductive Health Research Scholars' Symposium, Cincinnati, OH 2005.

"HPV and the Abnormal Pap Smear – What We've Learned in the Last Five Years", Primary Care Grand Rounds, Departments of Reproductive Medicine and Family Medicine, University of California San Diego, 2006.

RESEARCH SUPPORT

Completed

Women's Reproductive Health Research Scholars Program
Principal Investigator: Thomas R. Moore
Agency: NIH HD-99-001
Type: K12HD01259-04

Research Career Development Center in Reproductive Sciences
Period: September 2002-August 2007
The major goal of this project is to provide protected time and salary support for 3-5 years to junior academic faculty in a mentor-based environment that will foster the development of clinician-scientists in translational research in women's health.

"Role of Cytoplasmic P27KIP1 in Cell Motility and Metastasis"
Principal Investigator: Cheryl C. Saenz
Mentor: Steven F. Dowdy
Agency: Rebecca and John Moores UCSD Cancer Center Mentored Translational Research Award
Period: December 2005-November 2006
This project aims to study the role of p27KIP1 in cell motility and the relevance of its cytoplasmic localization in the development of tumor invasion and metastasis.

"Transducible Therapeutic TAT-siRNAs: Treatment of Terminal Metastatic Ovarian Cancer"
Principle Investigator: Cheryl C. Saenz
Co- Principle Investigator: Steven F. Dowdy
Agency: Rebecca and John Moores UCSD Cancer Center Collaborative Translational Research Award
Period: August 2004-July 2005
This project aims to combine protein transduction with the specificity of RNAi, to specifically kill tumor cells in terminal metastatic ovarian peritoneal carcinomatosis mouse models by targeting genes that allow these tumor cells to survive.

"Targeting of p53-activating Peptide to CXCR4 Receptor on Cancer Cells to Enhance Anti-tumor Efficacy"
Principal Investigator: Cheryl C. Saenz
Agency: UCSD Academic Senate
Period: July 2004-June 2005
The goal of this project is to enhance the delivery of anti-cancer peptides to tumor cells expressing specific receptors by linking the peptides to ligands that bind these receptors.

"Treatment of Terminal Metastatic Ovarian Carcinoma by Transducible Therapeutic siRNAs"
Principal Investigator: Cheryl C. Saenz
Agency: The Gynecologic Cancer Foundation/Florence and Marshall Schwid Ovarian Cancer Grant
Period: January 2004-December 2004
The goal of this project is to combine two recent technological advances, in vivo protein transduction delivery with the specificity of RNAi, to specifically kill tumor cells in ovarian peritoneal mouse models by silencing the genes that allow these tumors to escape apoptosis.

"Evaluation of Endometrial Stripe Thickness in Women with Endometrial Cancer"
Principal Investigator: Cheryl C. Saenz
Agency: UCSD Academic Senate
Period: January 2001-December 2002
The goal of this project was to determine the thickness of the endometrial stripe as measured by transvaginal ultrasound in women diagnosed with endometrial cancer.

ABSTRACTS

Gurin CC, Plaxe SC: Ten-year trends in pre-invasive and invasive cervical neoplasia in Southern California. Gynecol Oncol 58:409-410, 1995.

Gurin CC, Hann L, Venkatraman E, Curtin JP, Barakat RR: Correlation of uterine surgical pathology with preoperative ultrasound measurement of endometrial stripe thickness. Gynecol Oncol 64:2, 1997.

Gurin CC, Blank S, Venkatratman E, Mychalczak B, Curtin JP, Barakat RR: Pathologic risk factors and outcomes for isolated adnexal metastases in endometrial cancer. Gynecol Oncol 64:2, 1997.

Gurin CC, Krygier A, Barakat RR: The practice of ovarian conservation in premenopausal endometrial cancer patients: A survey of the membership of the SGO. Gynecol Oncol 68:1, 1998.

Blank SV, Gurin CC, Barakat RR: Clinicopathologic features of endometrial cancer occurring in patients with a family history suspicious for hereditary nonpolyposis colorectal cancer. Gynecol Oncol 68:1, 1998.

Gurin CC, Federici MG, Kang L, Boyd J: Causes and consequences of microsatellite instability in endometrial carcinoma. Gynecol Oncol, 72:32, 1999.

Daly TL, Rock CL, Moskowitz A, Pidding A, Saenz CC, Behling C: Carotenoid-rich diet intervention for women diagnosed with cervical intraepithelial neoplasia. J Amer Dietetic Assoc, A-91, 2000.

Saenz CC, Snyder EL, Meade BR, Dowdy SF: Treatment of peritoneal carcinomatosis by a transducible p53-activating peptide. Society of Gynecol Onc, Feb 2004.

BOOK CHAPTERS

Gurin CC and Mitchell MS. (1998). Principles of Immunology and Immunotherapy. In: Synopsis of Gynecologic Oncology, Fifth edition. Morrow CP, Curtin JP, Townsend DE, editors. Churchill Livingstone.

Saenz CC and Dowdy SF. (2005). Transmembrane Delivery of Protein and Peptide Drugs into Cancer Cells. In: Delivery of Protein and Peptide Drugs in Cancer, Torchilin V, editor. Imperial College Press.

PUBLICATIONS

Flamant F, Gurin CC, Sorge JA: An embryonic DNA-binding protein specific for the promoter of the retrovirus long terminal repeat. Molec Cell Biol 7:3548-3553, 1987.

Gurin CC, Federici MG, Kang L, Boyd J: Causes and consequences of microsatellite instability in endometrial carcinoma. Cancer Research 59:462-466, 1999.

Gemignani ML, Chi D, Gurin CC, Curtin JP, Barakat RR: Splenectomy in recurrent epithelial ovarian cancer. Gynecol Oncol 72:407-410, 1999.

Hull AD, Salerno CC, Saenz CC, Pretorius DH: Three-dimensional ultrasonography and the diagnosis of placenta percreta with bladder involvement. J Ultrasound Med 18:853-856, 1999.

Rock CL, Moskowitz A, Huizar B, Saenz CC, Clark JT, Daly TL, Chin H, Behling C, Ruffin MT 4th.: High vegetable and fruit diet intervention in premenopausal women with cervical intraepithelial neoplasia. J Am Diet Assoc 101:1167-1174, 2001.

Snyder EL, Meade BR, Saenz CC, Dowdy SF: Treatment of terminal peritoneal carcinomatosis by transducible p53 activating peptide. PLoS-Biology 2:186-193, 2004.

Eitan R, Saenz CC, Venkatraman ES, Hann L, Bach, A, Gretz E, Barakat RR, Chi DS. Pilot study prospectively evaluating the utility of the measurement of preoperative sonographic endometrial thickness in patients with endometrial cancer. Menopause 12:27-30, 2005.

Snyder EL*, Saenz CC*, Denicourt C, Meade BR, Cui X, Kaplan IM, Dowdy SF. Selective targeting and killing of tumor cells expressing the CXCR4 receptor by transducible anti-cancer peptides. Cancer Res. 65:10646-50, 2005. [*Denotes Co-First Authors]

Denicourt C., Saenz CC, Datnow B., Cui X., Dowdy S.F. Relocalized p27 Kip1 Tumor Suppressor. (in press).

Faculty