Department of Reproductive Medicine

Douglas Woelkers

Associate Clinical Professor, NS, Division of Perinatal Medicine

Administrative Office:
619-543-6906
Email:
dwoelkers@ucsd.edu


MD

Stanford University 1992

Internship

Department of Reproductive Medicine, Obstetrics and Gynecology

University of California, San Diego,1992-1993

Residency

Department of Reproductive Medicine, Obstetrics and Gynecology

University of California, San Diego,1993-1996

Fellowship

Magee Women's Hospital, Maternal-Fetal Medicine

University of Pittsburgh, 1996-1999

Licensure

California 1993

Board Certifications

American Board of Obstetrics and Gynecology - Subspecialty in Maternal-Fetal Medicine, 2003, Part I

American Board of Obstetrics and Gynecology - General Obstetrics and Gynecology, 2000

Honors and Awards

American Association of Professors of Gynecology and Obstetrics Teaching Award, Summer 2006

Class Valedictorian, National Center for Leadership in Academic Medicine, Winter/Spring 2003

NIH/Perinatal Research Society Young Investigator Award - July 2002

American Association of Obstetricians and Gynecologists Foundation Fellowship - July 1998

Memberships

UCSD Physician-Scientists Colloquium, September 2004

Fellow, American College of Obstetrics and Gynecology, April 2002 - present

Member, North American Society for the Study of Hypertension in Pregnancy, July 2001 - present

Member, Society for Maternal Fetal Medicine, July 1997 - present

External Professional Activities

Journal Reviewer, Gynecologic and Obstetric Investigation, June 2004

Moderator, Women's Cardiovascular Health and Menopause, Soroptomists Club Annual Meeting, San Diego CA, April 2004

Presentation, "Thrombophilia During Pregnancy", 2nd Annual Perinatal Symposium, San Diego CA, January 2004

Fund-Raising and Scientific Program Co-Chair, Annual Meeting of the North American Society for the Study of Hypertension in Pregnancy, 2004-2006

Presentation, "Preeclampsia: More than Just Pregnancy-Induced Hypertension", UCSD Cardiovascular Science Conference Series, La Jolla CA, October 2003

Presentation, "Endothelial Susceptibility" and "Antibodies to Oxidized LDL in Pregnancy and Preeclampsia",

North American Society for the Study of Hypertension in Pregnancy, Winston-Salem NC, July 2003

Board Member, North American Society for the Study of Hypertension in Pregnancy, July 2003 - present

Grant Reviewer, Canadian Institutes of Health Research, September 2003

Presentation, "Expression of Steroid Hormone Receptors in Vascular Endothelium", WRHR Scholar's Symposium, Washington DC, April 2003

Presentation, "Endothelial Activation in Pregnancy and Preeclampsia", American Association of Obstetricians and Gynecologists Foundation Scholars' Lecture, Hot Springs VA, September 2002

Presentation, "Endothelial NF-kB Activity in Pregnancy and Preeclampsia", WRHR Director's Meeting, San Diego. Ca. May 2002

Other Activities

-Research Activities

Approved Human Subjects Research Protocols

Autoantibodies to Oxidized LDL in Women with Preeclampsia, IRB # 011123, 10/4/01-10/4/03

Determinants of Atherosclerosis and Fetal Natural Immunity, IRB # 040240, 2/9/04-2/25/05

Sleep Disordered Breathing and Preeclampsia, IRB # 040614, 4/19/04-5/5/05

Early Onset Infection and Antibiotic Resistance in Newborn Infants, IRB #041511, 10/6/04-10/6/05

Sleep Disordered Breathing in Pregnancy, IRB #051060, 9/1/05 - 9/1/06

Utilization of MR Spectroscopy in Detecting Early Intrauterine Fetal Brain Hypoxia and Ischemia, IRB # 050781, 5/1/06 - 5/1/08

Urinary Predictors of Preeclampsia, IRB # 060621, 7/27/06 - 7/27/08

Detection of Proteinuria in Preeclampsia, IRB # 060651, 6/26/06 - 6/26/08

-Community Activities

Member, California Sierra Club, June 1987

Member, California League of Conservation Voters, June 1992

St. Teresa Carmel, Catholic Church

Member, Environment California, January 2003

Published Work

Original Articles

Casele HL, Laifer SA, Woelkers DA, Venkataramanan R. Changes in the pharmacokinetics of the low-molecular-weight heparin enoxaparin sodium during pregnancy. American Journal of Obstetrics & Gynecology 1999;181(5 Pt 1):1113-7.

The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul;46(7):1353-63.

Lindegaard MLS, Madsen EM, Woelkers DA, Binder CJ, Damm P, Mathiesen E, Nielsen LB. Proatherogenic low density lipoprotein metabolism in infants of mothers with diabetes. Diabetes (In Press).

Invited Articles:

Woelkers DA, Caritis SN. "Preterm Labor and Delivery." In The Encyclopedia of Reproduction, eds. E. Knobil and J. Neill. San Diego: Academic Press, 1999. (1037-1052).

Woelkers DA, Roberts JM. "The Endothelium in Preeclampsia." In The Handbook of Hypertension, eds. W. Birkenhager and J.L. Reid. Amsterdam: Elsevier Science, 2000. (pp. 126-162).

Woelkers DA. "Maternal Cardiovascular Disease and Fetal Growth and Development". In Fetal and Neonatal Physiology , eds. Polin, Fox & Abman. Philadelphia: Harcourt, 2004 pp 142-160.

Abstracts:

Casele H, Woelkers DA, Laifer SL. "Pregnancy outcome after liver transplantation." 17th Annual Meeting of the Society of Perinatal Obstetricians, 1997.

Woelkers DA, Craig WY, Roberts JM. "Auto-antibodies to malondialdehyde-modified low density lipoprotein (LDL) are not elevated in hypertensive diseases of pregnancy or IUGR. " 11th World Congress of the International Society for the Study of Hypertension in Pregnancy, 1998.

Vullaganti M, Woelkers DA, Crombleholme WR, Ness RB, Roberts JM. "Uric acid is elevated in early pregnancy in women destined to develop preeclampsia." 46th Annual Meeting of the Society for Gynecologic Investigation, 1999.

Woelkers DA, Crombleholme WR, Ness RB, Roberts JM. "Serum proteins are oxidatively modified in preeclampsia." 46th Annual Meeting of the Society for Gynecologic Investigation, 1999.

Woelkers DA, Ness RB, Crombleholme WR, Roberts JM. "Nuclear Factor Kappa-B (NF-kB) is not activated in endothelial cells exposed to plasma from preeclamptic women." 47th Annual Meeting of the Society for Gynecologic Investigation, 2000.

Woelkers DA, Ness RB, Crombleholme WR, Roberts JM. "In vitro activation of nuclear factor kappa B (NF-kB) in endothelial cells exposed to plasma from women with preeclampsia." 48th Annual Meeting of the Society for Gynecologic Investigation, 2001.

Woelkers D, Crombleholmbe W, Ness R, Roberts J. "Endothelial cell activation in preeclampsia: a loss of refractoriness to proinflammatory mediators?" 49TH Annual Meeting of the Society for Gynecologic Investigation, 2002.

Woelkers D, Moore TR, Witztum JL. "Estrogen receptor-B expression in vascular endothelium is reduced by exposure to inflammation". 50th Annual Meeting of the Society for Gynecologic Investigation, 2003.

Woelkers D, Moore TR, Witztum JL. "Effects of steroid hormones on endothelial cell estrogen receptor expression". 50th Annual Meeting of the Society for Gynecologic Investigation, 2003.

Woelkers D, Moore TR, Witztum JL. "IgM Antibodies to OxLDL are elevated in the human fetus". 5th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, 2004.

Woelkers D, Moore TR, Witztum JL. "Antibodies to Oxidized LDL are not elevated in preeclampsia despite an increase in LDL oxidation". 51st Annual Meeting of the Society for Gynecologic Investigation, 2004.

Clinical Guidelines:

Woelkers DA. "Thrombophilia in Pregnancy." One-to-One Clinical Guideline for UPMC Health System, 2000.

Woelkers DA. "Consensus Guidelines for Anticoagulation in Pregnancy". 2000. Division of Maternal-Fetal Medicine, Magee Womens Hospital, Pittsburgh, PA.

Work in Progress:

Maternal and fetal antibodies to oxidized LDL and the state of lipid modification in pregnancy, preeclampsia, and growth restriction. UCSD.

Oxidized LDL in newborn rat offspring of nutritional model of intrauterine programming. Ohmid Korram, Mike Ross. UCLA.

Phage display library of germline immunoglobulin genes from normal human newborns. Joseph Witztum, Sohvi Horrkko, Lotte Hansen. UCSD.

Faculty


Current Fellows in Maternal-Fetal Medicine:

  • Charlotte Conturie
  • Victoria Fratto
  • Tiffany Herrero
  • Jill McCaulley