Department of Reproductive Medicine
Obstetrics and Gynecology

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Department of Reproductive Medicine

David Natale, PhD

Division of Reproductive Endocrinology and Infertility


Assistant Professor of Reproductive Medicine


  • PhD - Univrsity of Western Ontario, 2003
  • Postdoctoral Fellowship - University of Calgary, 2003-2008


Link to Dr Natale's lab

Contact Information:





Administrative Assistant:

  • Ruth Montouri - 858.534.1140


Research Interests

The goal of our research is to learn how we can support the development of the healthiest babies possible. In the United States, 8-10% of pregnancies are affected by conditions such as intrauterine growth restriction (IUGR) or preeclampsia. Epidemiological studies of groups of babies born growth restricted have demonstrated that these children have an increased incidence of developing diseases as adults that include type II diabetes, hypertension and obesity. This relationship has been termed the Developmental Origins of Health and Disease and refers to fetal programming that results from changes in the uterine environment during pregnancy. The job of the placenta is to establish and maintain the intrauterine environment throughout pregnancy to support fetal growth and development. My lab is focused on understanding how the placenta forms and functions during a healthy pregnancy as well as in pregnancies complicated by IUGR, diabetes and other pathologies of pregnancy. We use both in vitro and in vivo mouse models to investigate the role of trophoblast stem and progenitor cells in placental development and function throughout gestation




  • URGC Travel Award, University of Calgary – International Federation of Placenta Associations Annual Meeting, Geilo, Norway, 2011

  • University of Queensland International Collaboration Travel Award - Dr. David Simmons, University of Queensland, Brisbane, Australia, 2011

  • Y. W. (Charlie) Loke Travel Award – 11th Annual Meeting of the International Federation of Placenta Associations (IFPA), Glasgow, Scotland, 2005

  • Invited Participant. British Council/UK Science, International Networking for Young Scientists (INYS) Workshop on Stem Cell Biology. Cambridge, UK, 2005

  • Obstetrics and Gynaecology Research Award, University of Western Ontario, 2001
  • Stavraky Teaching Award, Department of Physiology, University of Western Ontario, 2000
  • Obstetrics and Gynaecology, Research Award, University of Western Ontario, 1998
  • Student Research Competition (Finalist), International Embryo Transfer Society Annual Meeting. Boston, MA, USA, 1998


Recent Publications



For a full list of publications in PubMed click HERE