Assistant Professor of Reproductive Medicine
Division of Maternal-Fetal Medicine

Ph.D. in Reproductive Physiology, Beijing Agricultural University, P.R. China, 1992
Postdoctoral Fellow, Baylor College of Medicine, Houston, TX, 1993-1995
Postdoctoral Fellow, University of Kansas School of Medicine, Kansas, 1995-1998

telephone: 619 - 543 - 7279
Fax: 619 - 543 - 2919
e-mail: dochen@ucsd.edu

Teaching: Maternal Physiology, Fetal Physiology

Research Interest: Uteroplacental Vascular Endothelial Cell Biology, Hormone, Corpus Lutea

Current Research Focus: Our laboratory investigates maternal uterine and maternal-fetal placental vascular

Representative Publications:

• Chen-DB, Bird-IM, Zheng-J, Magness-RR. 2004 Membrane estrogen receptor dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology 145: 113-125



• Chen-DB, Davis-JS. (2003) Epidermal growth factor stimulates c-fos and c-jun mRNA expression through Raf-1/MEK1/ERK2/1 dependent and independent pathways bovine luteal cells. Molecular and Cellular Endocrinology 200: 141-154



• Tsoi-CM, Wen-YX, Jin-Young Chung, Chen-DB, Magness-RR, Zheng-J. (2002) Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells. Molecular and Cellular Endocrinology 196: 95-106



• Chen-DB, Zangl-A, Zhao-Q, Markley-JL, Zheng-J, Bird-IM, Magness-RR (2001) Ovine caveolin-1: cDNA cloning, E. Coli. expression, and association with endothelial nitric oxide synthase. Molecular and Cellular Endocrinology 175: 41-56



• Chen-DB, Fong-HW, Davis-JS (2001) Induction of c-fos and c-jun mRNA expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent ERK MAPK signaling pathway in bovine luteal cells. Endocrinology 142: 887-895



• Chen-DB, Westfall-SD, Fong-HW, Roberson-MS, Davis-JS (1998) Prostaglandin F2alpha activates the Raf/MEK1/MAPK signaling cascade in bovine luteal cells. Endocrinology 139: 3876-3885



• Mamluki-R, Chen-DB, Greber-Y, Zichel-W, Davis-JS, Meidan-R (1998) Characterization of prostaglandin F2alpha and LH receptor expression in different bovine luteal cell types. Biology of Reproduction 58: 849-856



• Chen-DB, Yang-ZM, Hilsenrath-R, Le-SP, Harper MJK (1995) Stimulation of prostaglandin (PG) F2alpha and PGE2 release by tumor necrosis factor-alpha and interleukin-1beta in cultured human luteal phase endometrial cells. Human Reproduction 10: 2773-2780



• Kudolo-GE, Yang-YQ, Chen-DB, Jones-MA, Harper-MJK (1995) Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of the rabbit endometrium. Journal of Reproduction and Fertility. 105: 315-324



• Yang-ZM, Le-SP, Chen-DB, Cota-J, Yosukawa-K, Harper-MJK (1995) Leukemia inhibitory factor (LIF), LIF receptor and gp130 in mouse uterus during early pregnancy. Molecular Reproduction and Development. 42: 407-414



• Chen-DB, Hilsenrath-R, Yang-ZM, Le-SP, Kim-SR, Choung-JC, Poindexter AN III, Harper-MJK (1995) Leukemia Inhibitory factor in human endometrium during the menstrual cycle: Cellular origin and action on glandular epithelial cell prostaglandin production in vitro. Human Reproduction 10: 911-918