Internship - Medicine, Queen Mary Hospital, Hong Kong, l954-l955
Residency, Obstetrics and Gynecology
Johns Hopkins Hospital, Baltimore, Maryland, l956-l960

Specialty Board Certification: American Board of Obstetrics and Gynecology, 1961
American Board of Reproductive Endocrinology, 1975

telephone: 858 - 534 - 8930
fax: 858 - 534 - 8856
email: Andi Hartgrove ahartgrove@ucsd.edu

Dr. Samuel S.C. Yen, a member of the Institute of Medicine, National Academy of Science, is an internationally acclaimed authority in the field of reproductive endocrinology. Dr. Yen's pioneering work in the area of neuroendocrine regulation of the menstrual cycle has provided many insights into problems such as anovulatory infertility, premenstrual syndrome and the menopause. Information gleaned from his over 450 published research studies and 40 book chapters have been compiled in a text entitled Reproductive Endocrinology (presently in its 4th edition) which remains the most comprehensive and authoritative book in that field to date.

In 1992, Dr. Yen's outstanding contribution to the field of reproductive neuroendocrinology was recognized as, what many considered, the "triple crown" for scientists in this field. Dr. Yen was awarded the Distinguished Scientist Award by the Society of Gynecologic Investigation; the Rhône-Poulenc Rorer Clinical Investigator Award by the Endocrine Society, and the Distinguished Achievement Award by the American Fertility Society. More recently, he was honored by the Simpson Medal by the University of Edinburgh, Scotland. Dr. Yen's expertise, innovative ideas and dynamic teaching style have earned him a reputation not only as an outstanding researcher but also as a teacher of exceptional capability. He has trained over 90 fellows world-wide during the past 27 years.

Research Interests:

• Neuroendocrine regulation of reproductive cycles

• Biological rhythms - related to reproduction

• Pregnancy induced neuroendocrine-metabolic alterations
  

Representative Publications:

• Yen SSC, Vela P, Rankin J, Littell AS: 1970 Hormonal relationships during the menstrual cycle. JAMA 211:1513-1517.

• Yen SSC: 1964 Abnormal carbohydrate metabolism and pregnancy. Am J Obstet Gynecol 90:468-473.

• Yen SSC, Vela P, Rankin J: 1970 Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 30:435-442.

• Yen SSC, Rebar R, VandenBerg G, Judd H: 1973, Hypothalamic amenorrhea and hypogonadotropism: Responses to synthetic LRF. J Clin Endocrinol Metab 36:811-816.

• Casper RF, Yen SSC: 1979 Menopausal flushes: A neuroendocrine link with pulsatile luteinizing hormone secretion. Science 205:823-825.

Recent Publications:

• Cagnacci, A., Soldani, R., and Yen, S.S.C.: Melatonin enhances cortisol levels in aged but not young women. European J Endocrinology, 133:691-695, 1995.

• Holden, J.P., Butzow, T.L., Laughlin, G.A., Ho, M., Morales, A.J., and Yen, S.S.C.: Regulation of insulin-like growth factor binding protein-1 (IGFBP-1) during the 24h metabolic clock and in response to hypoinsulinemia induced by fasting and sandostatin in normal women. J Soc Gynec Invest 2: 38-44, 1995.

• Yen, S.S.C., Laughlin, G.A., and Morales, A.J.: Evidence for a role of growth hormone-insulin-like growth factor system in the polycystic ovary syndrome (PCOS). In The Somatotrophic Axis and the Reproductive Process in Health and Disease, Serono Symposia, 17:212-219, 1995.

• Butzow, T.L., Kettel, L.M., and Yen, S.S.C.: Clomiphene citrate reduces serum insulin-like growth factor-I (IGF-I) and increases sex hormone-binding globulin (SHBG) levels in women with polycystic ovary syndrome. Fertil & Steril 63: 1200-1203, 1995.

• Murphy, A.A., Kettel, L.M., Morales, A.J., Roberts, V.J., Parmley, T., and Yen, S.S.C.: Endometrial effects of long term, low dose administration of RU 486. Fertil & Steril 63: 761-766, 1995.

• Murphy, A.A., Morales, A.J., Kettel, L.M., and Yen, S.S.C.: Regression of uterine leiomyomata to the antiprogesterone RU486: dose response effect. Fertil & Steril 64: 187-190, 1995.

• Lin, L., Roberts, V.J., and Yen, S.S.C.: Expression of human gonadotropin releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion. J Clin Endocrinol Metab 80: 580-585, 1995.

• Cagnacci, A., Soldani, R., and Yen, S.S.C.: Exogenous melatonin enhances luteinizing hormone levels of women in the follicular but not in the luteal menstrual phase. Fertil & Steril 63: 996-999, 1995.

• Cagnacci, A., Soldani, R., and Yen, S.S.C.: Hypothermic effect of melatonin and nocturnal core body temperature decline are reduced in aged women. J Appl Physiol 78: 314-317, 1995.

• Apter, D., B tzow, T., Laughlin, G.A., and Yen, S.S.C.: Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J Clin Endocrinol Metab, 80: 2966-2973, 1995.

• Yen, S.S.C., Morales, A.J., and Khorram, O.A.: Replacement of DHEA in aging men and women: potential remedial effects. Annals NY Acad Sci 774:128-142, 1995.

• Soldani, R., Cagnacci, A., Paoletti, A.M., Yen, S.S.C., and Melis, G.B.: Modulation of anterior pituitary luteinizing hormone response to gonadotropin-releasing hormone by insulin-like growth factor I in vitro. Fertil Steril 64:634-637, 1995.

• Kettel, L.M., Murphy, A.A., Morales, A.J., Ulmann, A., Baulieu, E.E., and Yen, S.S.C.: Treatment of endometriosis with the antiprogesterone mifepristone (RU486). Fertil & Steril 65: 23-28, 1996.

• Cagnacci, A., Soldani, R., Laughlin, G.A., and Yen, S.S.C.: Modification of circadian body temperature rhythm during the luteal menstrual phase: the role of melatonin. J Appl Physiol, 80:25-29, 1996.

• Yen, S.S.C., Morales, A.J., Laughlin, G.A., B tzow, T., Baumann, G., and Maheshwari, H.: Insulin, somatotrophic and LH axes in lean and obese women with polycystic ovary syndrome (PCOS): common and distinct features. Serono Symposia, Frontiers in Endocrinology 19:193-206, 1996.

• Kettel, L.M., DePaolo, L.V., Morales, A.J., Apter, D., Ling, N., and Yen, S.S.C.: Circulating levels of follistatin from puberty to menopause. Fertil & Steril 65:472-476, 1996.

• Morales, A.J., Laughlin, G.A., B�tzow, T., Maheshwari, H., Baumann, G., and Yen, S.S.C.: Insulin, somatotrophic and LH axes in lean and obese women with polycystic ovary syndrome (PCOS): common and distinct features. J Clin Endocrinol Metab 81:2854-2864, 1996.

• Asakura, H, Zwain, I, and Yen, SSC: Expression of genes encoding coritoctropin-releasing factor, type 1 CRF receptor (CRF-R1), and CRF-binding protein (CRF-BP) and localization of the gene products in the human ovary.  J Clin Endocrinol Metab, 82:2720-2725, 1997.

• Zwain, IH and Yen, SSC.  Neurosteroidogenesis in astrocytes, oligodendrocytes and neurons of cerebral cortex of rat brain.  Endocrinology 140:3843-3852, 1999.

• Yen, SSC, Dehydroepiandrosterone sulfate and longevity: New cludes for an old friend.  Proc, Natl Acd Science 98:8167-8169, 2001.

• Zwain, IH, Arroyo, A., Amato, P., and Yen, SSC.  A role for hypothalamic astrocytes in estradiol and dehydroepiandroserone regulation of GnRH release by GnRH neurons.  Neuroendocrinology 75:375-383, 2002.

• Arroyo, A, Pernasetti, F, Vasilyev, V, Amato, P, Yen, SSC, and Mellon, PL.  A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty.  Clinical Endocrinology, (Oxf) Aug 2002.