Department of Reproductive Medicine
Obstetrics and Gynecology

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Research Programs

Division of Gynecologic Oncology

       Schlepfer Lab

          Our lab’s goal is to understand how cancers spread from their tissue of origin to other sites in the body.   Our research interests

          are focused upon the molecular signaling events that control cell migration and survival.  We hypothesize that there are important

          intracellular signaling proteins that act to integrate and regulate both motility and survival signals within cells


       Stupack Lab


Division of Maternal-Fetal Medicine

     Laurent Lab

          Our lab applies our expertise in human pluripotent stem cell research and genomics to understand the molecular mechanisms

          underlying normal and abnormal human development, in order to improve the health of mothers and babies.


     Natale Lab

          The Natale Lab uses mouse trophoblast stem cells and models of placental insufficiency to understand how the placenta

          develops and functions to support a healthy pregnancy


Division of Reproductive Endocrinology and Infertility

     The Center for Reproductive Science and Medicine

          The goal of the Center for Reproductive Science and Medicine at UC San Diego is to develop understanding of the

          fundamental mechanisms that cause disordered function of the hypothalamic-pituitary-ovarian axis in Polycystic Ovary

             Syndrome (PCOS). Polycystic ovary syndrome (PCOS) is the most common cause of female infertility, occurring in about 1 in

             10 women of childbearing age.  READ MORE


     Breen Church Lab

          The Breen Church lab focuses on: Neuroendocrine mechanisms controlling reproduction and fertility; Mechanisms underlying

          stress and stress-associated disease states on fertility; and Early life programming of delayed or deficient fertility.


     Cook-Andersen Lab

          The Cook-Anderson Lab is interested in : post-transcriptional regulation of gene expression; transcriptional silencing in the

          oocyte and oocyte maturation; early embryo development and embryonic genome activation, nuclear repromamming, the

          molecular basis of ovarian aging


     Duleba Lab


     Kauffman Lab

          We use a variety of molecular, cellular, physiological and neuroanatomical techniques to study how the brain and hormones

          interact to control reproduction in mammals.  More specifically, we assess how neural circuits stimulate or inhibit

          Gonadotropin-releasing hormone (GnRH) neurons, thereby regulating the neuroendocrine reproductive axis.


     Lawson Lab

          The main focus of the Lawson Laboratory is on understanding how the brain and pituitary interpret and respond to the

          various signals that control reproductive hormone synthesis and secretion.


     Mellon Lab

          We are interested in how the brain controls reproduction through the neuroendocrine system with emphases on development,

          hormone signaling, gene expression, circadian rhythm, and mouse models of human disease.


     Shimasaki Lab


     Thackray Lab

          The focus of our research is to understand the etiology and pathophysiology of PCOS using relevant mouse and tissue culture

          models.  We are currently studying the influence of genetic variation on gonadotropin hormone production and fertility.  We are

          also investigating interactions among metabolism, the gut microbiome and the reproductive axis in PCOS.


     Wilkinson Lab

          Our studies are centered on the impact of gene regulatory circuits in normal development and disease.